Cultivates and Processes Microbial and Cell Cultures

The Applikon BioBench from Getinge is a versatile stainless steel bench-scale bioreactor designed for precision in biopharmaceutical applications. Ideal for microbial and cell cultures, this equipment mimics commercial-scale processes in a compact form, maintaining essential geometric ratios. It supports operations like cultivation, sampling, draining, sterilization, heating, cooling, and mixing. With capacities ranging from 15 to 30 liters, it caters to scale-up studies and small-scale production of monoclonal antibodies, vaccines, and recombinant proteins. Its Sterilizable-in-Place feature minimizes contamination risks, while the open frame construction ensures easy maintenance. The bioreactor is built with durable 316L stainless steel, offering resistance to biofilms and ensuring compliance with cGMP standards. Customization options and engineering support are available to meet specific process demands.

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Facilitates Bioprocess Scale-Up and Cultivation

The Applikon BioPilot from Getinge is a versatile stainless steel bioreactor designed for biopharmaceutical and vaccine manufacturing. This multi-use pilot plant bioreactor simplifies the transfer from lab scale to production with its modular design and Sterilize-in-Place capability. It’s optimized for cultivating microbial and cell cultures, producing vital therapies like monoclonal antibodies and mRNA vaccines. With working volumes ranging from 20 to 200 liters, the BioPilot excels in scale-up studies, process optimization, and small-scale production. It features PLC automation for precise control and is constructed from pharma-grade 316L stainless steel, ensuring compliance with cGMP standards. The integrated magnetic agitator system and hygienic design minimize contamination risk, while its robust configuration supports both batch and continuous operations.

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Cultivates and Ferments Microbial and Cell Cultures

The Applikon BioProduction system from Getinge is a stainless steel bioreactor designed to meet the stringent demands of pharmaceutical and biopharmaceutical manufacturing. This system is engineered for precise control over cultivation and fermentation processes, making it ideal for producing vaccines, monoclonal antibodies, and various biological drugs. It operates using a fully automated Cultivation, Fermentation, and Sterilization process, which includes advanced temperature, pH, and DO2 control systems for optimal microbial and cell culture growth.

Applications span across pharmaceutical and biotech industries, where it supports the production of insulin, onco-therapeutic vaccines, and CAR-T cell therapies. Offering capacities for both pilot and full-scale production, it can handle volumes up to 5,000 liters. The system integrates seamlessly into existing lines with PLC control options for Siemens and Allen Bradley, providing flexibility in automation and remote monitoring via a DCS.

Energy-efficient design is achieved through its magnetically coupled agitation system, minimizing contamination risks while enhancing mixing efficiency. The bioreactors are fabricated with pharma-grade 316L stainless steel, featuring a surface finish of Ra < 0.4 micron, ensuring superior cleanability and resistance to biofilm buildup. The system is CIP/SIP capable, enhancing its hygiene standards and ease of maintenance. Compliance with cGMP and GAMP guidelines, along with extensive documentation support, facilitates seamless verification and validation protocols. With options for customization to fit specific process needs, including variable gas sparging systems and flexible control architectures, the BioProduction system ensures tailored solutions for any bioprocessing challenge.

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