Easy to use control for lab scale operation

The ez2-Control from Getinge Applikon is an easy to use control and measurement system for bioreactors and fermentors. The bioreactor control system offers high accuracy, a good insight and easy adjustment of pH, Temperature, dissolved Oxygen, Foam/Level and Agitation, which are crucial for any biopharmaceutical process.

The colour touch screen interface guides the user through the operation.  The adaptive control features allow the user to focus on the process while the controller keeps tight control on the important process parameters.

The new web-interface for ez2-Control with advanced user management option provides a clear overview of the bioprocess parameters. Also it allows back-ups, copies and predefined settings of configurations to be simply shared via USB.

The ez2-Control can be used to control a large variety of reaction environments: From autoclavable bioreactors, steam in place bioreactors, to Appliflex single use bioreactors, milipore Cell Ready single use bioreactors or HyClone SUB bioreactors.

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A Tailor-Made 3D Printed Alternative Micro-Bioreactor

AppliFlex ST disposable reactors from Getinge Applikon are customizable to individual requirements. Moreover, the company 3D prints its tailor-made single-use bioreactors, meaning it can accurately create a perfect clone at any time after completing the first order.

These bioreactors can be stirred, and the user can choose the type and number of impellers, liquid and gas additions, and sparger gas diffusers to create a bioreactor that suits their purpose. They could even design their own impeller and Getinge Applikon will create it.

The AppliFlex ST design caters for both cell culture at 500 millilitre / 3 litre volumes, and 500 millilitre microbial applications. The customisable design allows the user to specify their bioreactor, and therefore optimise the output. The fully removable top plate provides easy access to the product.

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Considerably small, real bioreactors

The MiniBio from Getinge Applikon is a range of bioreactors (250 ml, 500 ml and 1000 ml total volume) is a true scale down of the laboratory scale bioreactors in the 1 to 15-liter range. The Mini bioreactors systems have the same flexibility as the laboratory scale bioreactors, which means that the MiniBio systems can be customized to fit the demands of any process.

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Control system for small-scale bioreactors

MyControl from Getinge Applikon is the most advanced controller available for small-scale bioreactors, compatible with bioreactors ranging from 50 mL to 2,700 mL (working volume), and is easily convertible between microbial and cell culture configurations.

The built-in software interface allows you to access with a web browser via computer, tablet or smartphone, so you can manage your entire laboratory with ease.

It is pre-configured and ready to use. Adding additional control loops, sensors, actuators, or external I/O is also fast and easy, so you will receive a system that meets your exact process specifications! Moreover, it is modular, so you can change your configuration options in the future as your experimental objectives.

One control system can control: 250 ml up to 1000 ml MiniBio bioreactors, 1L up to 3 liter Autoclavable bioreactors, 3 liter Cellready single use bioreactors.

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Bioreactor vessel with single-use contact surfaces for mixing

Getinge Applikon is an authorized integrator for the HyClone S.U.B. bioreactors. The Hyclone is a fully functional and unique tank bioreactor mixing system which provides overhead mixing while maintaining sterility and integrity. A re-usable outer support container also provides a mixer motor, heating/cooling, control unit for integration with an external control system and a mobile skid.

This bioreactor operating system enables to set-up and the application of your processes in a reduced time-to-market, going from R+D to production in the shortest time.

The main features of this unique equipment are scalability, for both larger and smaller volume systems for research and process development; alternative Sparging, the product is also supplied with an open pipe and (optional) micro porous “frit”.

Single-use Non-invasive Sensors, like the ez-Control is capable of measuring both classical sensors for pH and Dissolved Oxygen as well as Fluorophore type sensors.

The combination of ez-Control and HyClone S.U.B. offers the advantages of Single-Use Processing.

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Rocking Single-Use Bioreactors from 10 up to 50 liter volume

The Single-use bioreactor Appliflex, from Getinge Applikon is a flexible bag bioreactor ideal for cell culture, specially the growth of animal cells like CHO cells, Hybridoma cell lines and insect cells like Sf-9, Sf-21 cells, also excellent working for the seeding of pre-seeding for larger cell cultivation systems.

Offering reliable measurement and control in rocking Single-Use Bioreactors from 10 up to 50-liter volume. The bag and sensors (pH, dissolved oxygen, T) are designed for single-use, in compliance with CE guidelines.

The control system (pH, DO, T, rpm) is formed by the standard Getinge Applikon ez-Control, which guarantees real-time measurement of pH, DO, T and rocking speed.

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3 liter single-use stirred tank bioreactor

The Single-use bioreactor CellReady 3L, from Getinge Applikon is a stirred tank bioreactor platform that works by eliminating the cleaning process, it is disposable, autoclave and assembles your traditional glass bioreactors, saving you downtime days, which sometimes represent quite a setback at the initial scale-up stage, due to the limited data available.

This Single-use bioreactor CellReady 3L, allows you to focus on experimentation and data analysis, getting you to faster conclusions.

The control system is formed by the standard Getinge Applikon ez-Controller, configured for a cell culture application, it measures and controls pH, temperature and dissolved oxygen (DO).

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Enhances oxygenation and bulk mixing for bacterial and fungi cultures

The Resonance Acoustic Mixer, from Getinge Applikon is a highly-efficient orbital-shaker replacement that dramatically enhances oxygenation and bulk mixing for bacterial and fungi cultures. Combined with the patented Oxy-Pump® stopper, oxygen transfer rates up to 6-fold higher than orbital-shaken cultures can be achieved. The Resonance Acoustic Mixer is an indispensable product for any cutting-edge biological laboratory.

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Pilot scale to production bioreactor control system

Getinge Applikon i-Control is an easy-to-operate Scalable bioreactor controller and utility console. This scalable control solution is used to control processes in bioreactor systems from laboratory scale to pilot plant and production scale. The i-control from Getinge Applikon is a human interface color touch screen device used to control the most important parameters at a laboratory scale scenery.

The seamless scale-ability saves time and money by offering a simple scale-up of a control strategy from research via pilot-plant to production. The simplicity of operation is one of the key features, allowing operation by cell biologists, and configurations to get adapted to changing process demands without the need of an engineer on-site.

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DO2 Sensor optimized for bioprocesses

The Dissolved Oxygen sensor is a measuring device that informs about the dissolved oxygen in biotechnology processes, which is a basis for process optimization and control.

The AppliSens Low-Drift DO2 sensor from Getinge Applikon is specifically designed for long-term, stable, and accurate measurements in bioprocesses, such as fermentation and cell culture applications. Designed to withstand repeated sterilizations without failure.

The DO2 sensor has a titanium membrane module to minimize the measurement drift, and the available autoclave polarization module allows you to reduce start-up time for your cultures.

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